Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PHB and SUMO4
Data Source:
HPRD
(in vivo)
PHB
SUMO4
Description
prohibitin
small ubiquitin like modifier 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Postsynaptic Density
Membrane
Mitochondrial Crista
Extrinsic Component Of Mitochondrial Outer Membrane
Mitochondrial Prohibitin Complex
Extracellular Exosome
Extrinsic Component Of Presynaptic Active Zone Membrane
Glutamatergic Synapse
GABA-ergic Synapse
Nucleus
SUMO Ligase Complex
Molecular Function
Complement Component C3a Binding
Complement Component C3b Binding
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Molecular_function
Protein Tag
Ubiquitin-like Protein Ligase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Ovarian Follicle Atresia
Osteoblast Differentiation
Immunoglobulin Production
Regulation Of Transcription, DNA-templated
Mitochondrial Calcium Ion Transmembrane Transport
Mitochondrion Organization
Signal Transduction
Activation Of Phospholipase C Activity
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Death
Negative Regulation Of Transcription By Competitive Promoter Binding
Histone Deacetylation
CD40 Signaling Pathway
Negative Regulation Of Cell Growth
Animal Organ Regeneration
Interleukin-17 Production
Response To Immobilization Stress
RIG-I Signaling Pathway
B Cell Activation
Negative Regulation Of Protein Catabolic Process
Response To Drug
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Modulation By Host Of Viral RNA Genome Replication
Response To Ethanol
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Complement Activation
Viral Entry Into Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
T-helper 17 Type Immune Response
Antiviral Innate Immune Response
Positive Regulation Of NIK/NF-kappaB Signaling
Activation Of Protein Kinase C Activity
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Protein Sumoylation
Cellular Response To Oxidative Stress
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of DNA Binding
Negative Regulation Of DNA Binding
Negative Regulation Of Transcription, DNA-templated
Regulation Of Protein Localization To Nucleus
Pathways
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Drugs
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Asthma (
31959851
30929738
32296059
29273806
)
Asthma (adult onset) (
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Cancer (
29299148
)
Coronary artery disease (
29212778
33020668
)
Diastolic blood pressure (
19430483
27841878
)
Lower body strength (
27325353
)
Metabolite levels (
23823483
)
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Restricted and repetitive behaviours in autism spectrum disorder (
28533516
)
Systolic blood pressure (
27841878
30578418
)
Dupuytren's disease (
28886342
)
Interacting Genes
25 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP3K10
MCM2
NCOR1
PTEN
RAF1
RB1
RBL1
RBL2
SEC22A
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
75 interacting genes:
ACADM
ACO2
ACTG1
ALDOA
ARHGDIA
ATP5F1B
CALR
CAT
CCT2
CCT5
CCT6A
CCT7
CLIC1
DNAJA1
DNAJB11
EIF3I
ENO1
ENO2
FOS
G6PD
GAPDH
GMPS
GSTP1
HNRNPD
HNRNPF
HNRNPH1
HNRNPL
HSPA1B
HSPA5
HSPA8
HSPA9
HSPD1
IDH1
IDH3A
IMPDH2
JUN
LDHB
LMNA
LMNB1
MRPS22
NFKBIA
NR3C1
PA2G4
PAFAH1B3
PDIA3
PDIA6
PGK1
PHB
PHGDH
PITHD1
PPA1
PRDX2
PRDX3
PRDX4
PRDX6
PRPS1
PSMC2
RACK1
RPSA
SF3B4
SPINT2
STAT1
STAT3
STIP1
STOML2
STRAP
TFAP2A
TOP2A
TPM3
TUBA1C
TXNL1
UBE2V1
VCP
VDAC1
ZPR1
Entrez ID
5245
387082
HPRD ID
01454
10584
Ensembl ID
ENSG00000167085
ENSG00000177688
Uniprot IDs
A8K401
P35232
Q53FV0
Q6EEV6
PDB IDs
1LU7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?