GGCX and PDCD5

Data Source:
HPRD (in vivo)

		GGCX	PDCD5
Description		gamma-glutamyl carboxylase	programmed cell death 5
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	DNA Binding Protein Binding Heparin Binding Acetyltransferase Activator Activity Beta-tubulin Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Blood protein levels ( 29875488) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet count ( 32888494) Red cell distribution width ( 32888494 27863252)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	15 interacting genes: ACP5 CDC42 CEP126 EEF1G KAT5 KDM1A LRIF1 NUDT3 OTUD5 PICK1 RAD18 TRIM35 UBE2D3 UTP14A VHL
Entrez ID		2677	9141
HPRD ID		00665	06843
Ensembl ID		ENSG00000115486	ENSG00000105185
Uniprot IDs		P38435	O14737
PDB IDs			1YYB 2CRU 2K6B
Enriched GO Terms of Interacting Partners?
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