GBE1 and PGD

Data Source:
HPRD (two hybrid)

		GBE1	PGD
Description		1,4-alpha-glucan branching enzyme 1	phosphogluconate dehydrogenase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytosol Extracellular Exosome
	Molecular Function	1,4-alpha-glucan Branching Enzyme Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Carbohydrate Binding Cation Binding 1,4-alpha-glucan Branching Enzyme Activity (using A Glucosylated Glycogenin As Primer For Glycogen Synthesis)	Phosphogluconate Dehydrogenase (decarboxylating) Activity NADP Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Generation Of Precursor Metabolites And Energy Negative Regulation Of Neuron Apoptotic Process	Pentose-phosphate Shunt Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Catabolic Process
Pathways		Glycogen synthesis Glycogen storage disease type IV (GBE1)	Pentose phosphate pathway
Drugs			Gadopentetic acid Dacarbazine Ketotifen 6-phospho-D-gluconic acid Nicotinamide 8-bromo-adenine dinucleotide phosphate
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cadmium levels ( 26025379) Chronotype ( 30696823) Extraversion ( 27918536) Hand grip strength ( 29691431) Intraocular pressure ( 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Iron status biomarkers (transferrin saturation) ( 28334935) Lead levels in blood ( 25820613) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Meat-related diet ( 32066663) Photic sneeze reflex ( 30899065) Processed meat consumption ( 32066663) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference ( 25673412)	Hemoglobin ( 32888494) Hepatocellular carcinoma ( 20676096) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: EPHB3 PGD PRMT6 RIPK3 TRDMT1	6 interacting genes: CDC42 CDK4 GBE1 LINC01554 LSM8 TERF1
Entrez ID		2632	5226
HPRD ID		01985	01391
Ensembl ID		ENSG00000114480	ENSG00000142657
Uniprot IDs		Q04446 Q59ET0	B4E2U0 P52209
PDB IDs		4BZY 5CLT 5CLW	2JKV 4GWG 4GWK 5UQ9
Enriched GO Terms of Interacting Partners?
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