GBE1 and TRDMT1

Data Source:
BioGRID (two hybrid)

		GBE1	TRDMT1
Description		1,4-alpha-glucan branching enzyme 1	tRNA aspartic acid methyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	1,4-alpha-glucan Branching Enzyme Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Carbohydrate Binding Cation Binding 1,4-alpha-glucan Branching Enzyme Activity (using A Glucosylated Glycogenin As Primer For Glycogen Synthesis)	RNA Binding TRNA Methyltransferase Activity TRNA (cytosine-5-)-methyltransferase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Generation Of Precursor Metabolites And Energy Negative Regulation Of Neuron Apoptotic Process	Response To Amphetamine TRNA Modification TRNA Methylation TRNA Stabilization
Pathways		Glycogen synthesis Glycogen storage disease type IV (GBE1)	tRNA modification in the nucleus and cytosol
Drugs			Pentamidine S-adenosyl-L-homocysteine Glycerin
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cadmium levels ( 26025379) Chronotype ( 30696823) Extraversion ( 27918536) Hand grip strength ( 29691431) Intraocular pressure ( 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Iron status biomarkers (transferrin saturation) ( 28334935) Lead levels in blood ( 25820613) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Meat-related diet ( 32066663) Photic sneeze reflex ( 30899065) Processed meat consumption ( 32066663) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference ( 25673412)	Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Telomere length ( 24478790)
Interacting Genes		5 interacting genes: EPHB3 PGD PRMT6 RIPK3 TRDMT1	14 interacting genes: APP COPS6 DDX24 EEF1A1 GBE1 LRIF1 NFRKB RBM48 SETDB1 SNRPD3 STX1A TBC1D2B UNC119 UTP14A
Entrez ID		2632	1787
HPRD ID		01985	16001
Ensembl ID		ENSG00000114480	ENSG00000107614
Uniprot IDs		Q04446 Q59ET0	A0A0U1U562 B4DQZ2 O14717 Q6ICS7 Q7Z3E4
PDB IDs		4BZY 5CLT 5CLW	1G55
Enriched GO Terms of Interacting Partners?
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