GBE1 and EPHB3

Data Source:
BioGRID (two hybrid)

		GBE1	EPHB3
Description		1,4-alpha-glucan branching enzyme 1	EPH receptor B3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuron Projection Receptor Complex
	Molecular Function	1,4-alpha-glucan Branching Enzyme Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Carbohydrate Binding Cation Binding 1,4-alpha-glucan Branching Enzyme Activity (using A Glucosylated Glycogenin As Primer For Glycogen Synthesis)	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Generation Of Precursor Metabolites And Energy Negative Regulation Of Neuron Apoptotic Process	Angiogenesis Urogenital System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Axonal Fasciculation Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis
Pathways		Glycogen synthesis Glycogen storage disease type IV (GBE1)	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cadmium levels ( 26025379) Chronotype ( 30696823) Extraversion ( 27918536) Hand grip strength ( 29691431) Intraocular pressure ( 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Iron status biomarkers (transferrin saturation) ( 28334935) Lead levels in blood ( 25820613) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Meat-related diet ( 32066663) Photic sneeze reflex ( 30899065) Processed meat consumption ( 32066663) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference ( 25673412)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965)
Interacting Genes		5 interacting genes: EPHB3 PGD PRMT6 RIPK3 TRDMT1	13 interacting genes: AFDN CRK EFNB3 ERBB2 FBXO7 FYN GBE1 HPCAL1 HSF2BP LNX1 NFRKB RASA1 RYK
Entrez ID		2632	2049
HPRD ID		01985	03502
Ensembl ID		ENSG00000114480	ENSG00000182580
Uniprot IDs		Q04446 Q59ET0	P54753
PDB IDs		4BZY 5CLT 5CLW	3P1I 3ZFY 5L6O 5L6P
Enriched GO Terms of Interacting Partners?
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