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URI1 and POLR2E
Data Source:
HPRD
(in vivo, in vitro)
URI1
POLR2E
Description
URI1 prefoldin like chaperone
RNA polymerase II, I and III subunit E
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Dendrite
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
RNA Polymerase III Complex
RNA Polymerase I Complex
Cytosol
Molecular Function
RNA Polymerase II Complex Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Phosphatase Inhibitor Activity
Phosphoprotein Binding
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Regulation Of Transcription By RNA Polymerase II
Response To Virus
Negative Regulation Of Phosphatase Activity
Negative Regulation Of Phosphoprotein Phosphatase Activity
Cellular Response To Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
MRNA Splicing, Via Spliceosome
Transcription-coupled Nucleotide-excision Repair
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
RNA Metabolic Process
Positive Regulation Of Type I Interferon Production
Somatic Stem Cell Population Maintenance
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Regulation Of Gene Silencing By MiRNA
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Cerebrospinal P-tau181p levels (
28247064
)
Diastolic blood pressure (
27841878
)
Serum urate levels in chronic kidney disease (
30181573
)
Cortical amyloid beta load (
29860282
)
Menopause (age at onset) (
26414677
)
Interacting Genes
10 interacting genes:
APP
ATF7
CIAO1
DMAP1
GTF2F2
ITCH
NEDD4
POLR2E
RPS6KB1
STAP1
29 interacting genes:
CHGB
FKBP14
FOS
GTF2B
GTF2F2
HSP90B1
IKBKG
IP6K3
ITCH
LZTR1
NEDD4
PML
POLR2A
POLR2C
POLR2D
POLR2F
POLR2G
POLR2H
POLR2K
POLR2L
SRPK1
SYT5
TAF15
TRIM29
TRIM55
TRIM63
UBE2D4
URI1
ZSCAN1
Entrez ID
8725
5434
HPRD ID
11943
15946
Ensembl ID
ENSG00000105176
ENSG00000099817
Uniprot IDs
O94763
B4DJ89
E5KT65
P19388
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
Enriched GO Terms of Interacting Partners
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