RAI14 and ITSN1

Data Source:
BioGRID (two hybrid)

		RAI14	ITSN1
Description		retinoic acid induced 14	intersectin 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytosol Cytoskeleton Cell Cortex Cell Junction	Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Lamellipodium Presynaptic Membrane Neuronal Cell Body Dendritic Spine Recycling Endosome Apical Dendrite Intracellular Vesicle Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Spermatogenesis Cell Differentiation	Exocytosis Endocytosis G Protein-coupled Receptor Signaling Pathway Brain Development Protein Transport Viral Process Endosomal Transport Cellular Protein Localization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Membrane Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis
Pathways			NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Left ventricular mass ( 19454037) Platelet count ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 31578528) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)	Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252) Tonsillectomy ( 27182965 28928442)
Interacting Genes		7 interacting genes: FEZ1 FEZ2 ITSN1 RND1 YWHAB YWHAG YWHAQ	87 interacting genes: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAP3K20 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SGIP1 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 VLDLR WASL WBP11 ZFPM2
Entrez ID		26064	6453
HPRD ID		09416	03898
Ensembl ID		ENSG00000039560	ENSG00000205726
Uniprot IDs		Q9P0K7	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs			1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?
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