RNF167 and SLC22A18

Data Source:
BioGRID (enzymatic study)

		RNF167	SLC22A18
Description		ring finger protein 167	solute carrier family 22 member 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Integral Component Of Membrane	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Symporter Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle	Excretion Organic Cation Transport Xenobiotic Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways			Organic cation transport Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Platelet count ( 32888494) Plateletcrit ( 32888494)	Apolipoprotein A1 levels ( 32203549) Bilirubin levels ( 19414484) Calcium levels ( 20705733) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Malaria ( 31844061) Total bilirubin levels ( 29403010)
Interacting Genes		17 interacting genes: ACTA1 AFG3L2 ATP2A1 CAPN3 MYH7 SLC22A18 SUMO1 TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2K UBE2N UBE2W	5 interacting genes: HSD17B11 NKX3-1 RNF167 TLCD4 TMX2
Entrez ID		26001	5002
HPRD ID		15261	04024
Ensembl ID		ENSG00000108523	ENSG00000110628
Uniprot IDs		I3L0L6 Q9H6Y7	E9PRM7 Q96BI1
PDB IDs
Enriched GO Terms of Interacting Partners?
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