RNF167 and AFG3L2

Data Source:
BioGRID (two hybrid)

		RNF167	AFG3L2
Description		ring finger protein 167	AFG3 like matrix AAA peptidase subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Integral Component Of Membrane	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Metallopeptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Mitochondrial Calcium Ion Homeostasis Righting Reflex Protein-containing Complex Assembly
Pathways			Processing of SMDT1
Drugs			ATP
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Blood metabolite levels ( 24816252) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		17 interacting genes: ACTA1 AFG3L2 ATP2A1 CAPN3 MYH7 SLC22A18 SUMO1 TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2K UBE2N UBE2W	5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167
Entrez ID		26001	10939
HPRD ID		15261	05205
Ensembl ID		ENSG00000108523	ENSG00000141385
Uniprot IDs		I3L0L6 Q9H6Y7	Q8TA92 Q9Y4W6
PDB IDs			2LNA 6NYY
Enriched GO Terms of Interacting Partners?
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