TSKU and SKIL

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSKU	SKIL
Description		tsukushi, small leucine rich proteoglycan	SKI like proto-oncogene
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Transforming Growth Factor Beta Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding SMAD Binding
	Biological Process	Growth Plate Cartilage Chondrocyte Development Cholesterol Metabolic Process Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Corpus Callosum Morphogenesis Lateral Ventricle Development Hippocampus Development Anterior Commissure Morphogenesis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Cholesterol Efflux Wound Healing Cholesterol Homeostasis Positive Regulation Of Hair Cycle Camera-type Eye Development Inner Ear Receptor Cell Stereocilium Organization Ciliary Body Morphogenesis Energy Homeostasis Bone Growth Negative Regulation Of Myofibroblast Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Positive Regulation Of Axonogenesis Lens Fiber Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Factor VII activity ( 30642921)	Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)
Interacting Genes		1 interacting genes: SKIL	96 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GAS8 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		25987	6498
HPRD ID		12152	01319
Ensembl ID		ENSG00000182704	ENSG00000136603
Uniprot IDs		A0A024R5J8 B3KRF9 Q8WUA8	P12757
PDB IDs			3EQ5 5C4V
Enriched GO Terms of Interacting Partners?
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