SAMHD1 and ARAP3

Data Source:
BioGRID (two hybrid)

		SAMHD1	ARAP3
Description		SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain	Ruffle Cytosol Cytoskeleton Plasma Membrane Lamellipodium
	Molecular Function	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Ribonuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DGTP Catabolic Process Immune Response Cellular Response To DNA Damage Stimulus Deoxyribonucleotide Catabolic Process Viral Process Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway RNA Phosphodiester Bond Hydrolysis DNA Strand Resection Involved In Replication Fork Processing	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nucleobase catabolism Interferon alpha/beta signaling	Rho GTPase cycle
Drugs
Diseases		Aicardi-Goutieres Syndrome (AGS)
GWAS		Height ( 28552196)	Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		11 interacting genes: ACTB APP ARAP3 DCAF1 DYSF FAM13B FBXO25 FBXO7 SUMO2 TIRAP TRIM21	10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2
Entrez ID		25939	64411
HPRD ID		08418	09441
Ensembl ID		ENSG00000101347	ENSG00000120318
Uniprot IDs		Q59H15 Q9Y3Z3	Q05CH1 Q8WWN8 Q9H7C1
PDB IDs		2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM	2KG5 2LNW 5JCP 5JD0 7A9B
Enriched GO Terms of Interacting Partners?
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