SAMHD1 and FAM13B

Data Source:
BioGRID (two hybrid)

		SAMHD1	FAM13B
Description		SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	family with sequence similarity 13 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain	Cytosol
	Molecular Function	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Ribonuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding	GTPase Activator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DGTP Catabolic Process Immune Response Cellular Response To DNA Damage Stimulus Deoxyribonucleotide Catabolic Process Viral Process Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway RNA Phosphodiester Bond Hydrolysis DNA Strand Resection Involved In Replication Fork Processing	Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nucleobase catabolism Interferon alpha/beta signaling	Rho GTPase cycle
Drugs
Diseases		Aicardi-Goutieres Syndrome (AGS)
GWAS		Height ( 28552196)	Atrial fibrillation ( 28416818 30061737 29892015) Autism spectrum disorder or schizophrenia ( 28540026) Plateletcrit ( 32888494)
Interacting Genes		11 interacting genes: ACTB APP ARAP3 DCAF1 DYSF FAM13B FBXO25 FBXO7 SUMO2 TIRAP TRIM21	8 interacting genes: AGTR1 CDC42 LINC00839 RAC1 SAMHD1 YWHAE YWHAG YWHAZ
Entrez ID		25939	51306
HPRD ID		08418	06464
Ensembl ID		ENSG00000101347	ENSG00000031003
Uniprot IDs		Q59H15 Q9Y3Z3	A0A2X0SG06 Q9NYF5
PDB IDs		2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM
Enriched GO Terms of Interacting Partners?
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