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AMBP and A2M
Data Source:
HPRD
(in vivo, in vitro)
AMBP
A2M
Description
alpha-1-microglobulin/bikunin precursor
alpha-2-macroglobulin
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Cytosol
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Calcium Channel Inhibitor Activity
IgA Binding
Heme Binding
Protein Homodimerization Activity
Calcium Oxalate Binding
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Biological Process
Receptor-mediated Endocytosis
Cell Adhesion
Female Pregnancy
Negative Regulation Of Endopeptidase Activity
Viral Process
Protein-chromophore Linkage
Protein Catabolic Process
Heme Catabolic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Immune Response
Negative Regulation Of Complement Activation, Lectin Pathway
Platelet Degranulation
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Stem Cell Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Scavenging of heme from plasma
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly
Drugs
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Blood protein levels (
29875488
)
Refractive error (
32231278
)
Interacting Genes
12 interacting genes:
A2M
ALB
COX8A
DAAM1
ENO1
F2
FHL3
FN1
GRB2
PIK3CA
PIK3R3
STAT3
96 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
Entrez ID
259
2
HPRD ID
01467
00072
Ensembl ID
ENSG00000106927
ENSG00000175899
Uniprot IDs
P02760
P01023
PDB IDs
1BIK
3QKG
4ES7
4U30
6EJ7
6EJ8
6EJ9
6EJA
6EJB
6EJC
6EJD
1BV8
2P9R
4ACQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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