PLEKHG4 and RIN1

Data Source:
BioGRID (two hybrid)

		PLEKHG4	RIN1
Description		pleckstrin homology and RhoGEF domain containing G4	Ras and Rab interactor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Catalytic Activity	Endocytosis Signal Transduction Positive Regulation Of GTPase Activity
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 28869591) Refractive error ( 32231278)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	50 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CCM2 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH NRAS PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		25894	9610
HPRD ID		10890	05813
Ensembl ID		ENSG00000196155	ENSG00000174791
Uniprot IDs		A0A024R6X4 Q58EX7	A0A0S2Z4U0 Q13671
PDB IDs
Enriched GO Terms of Interacting Partners?
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