PLEKHG4 and DCUN1D5

Data Source:
BioGRID (two hybrid)

		PLEKHG4	DCUN1D5
Description		pleckstrin homology and RhoGEF domain containing G4	defective in cullin neddylation 1 domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Ubiquitin Ligase Complex Nucleus Spindle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Regulation Of Catalytic Activity	Regulation Of Cell Growth Cellular Response To DNA Damage Stimulus Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways			Neddylation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 28869591) Refractive error ( 32231278)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Interleukin-10 levels ( 22205395) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)
Interacting Genes		65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648	11 interacting genes: CAND1 CHUK CUL2 CUL3 HUS1 LNX1 PICK1 PLEKHG4 RCHY1 UBE2F UBE2M
Entrez ID		25894	84259
HPRD ID		10890	14520
Ensembl ID		ENSG00000196155	ENSG00000137692
Uniprot IDs		A0A024R6X4 Q58EX7	A0A024R3A2 B4DP84 Q9BTE7
PDB IDs
Enriched GO Terms of Interacting Partners?
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