WHRN and SPC24

Data Source:
BioGRID (two hybrid)

		WHRN	SPC24
Description		whirlin	SPC24 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Tip Ciliary Basal Body Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance	Cell Cycle Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Usher syndrome (US) Deafness, autosomal recessive
GWAS			Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN	8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN
Entrez ID		25861	147841
HPRD ID		09718	15464
Ensembl ID		ENSG00000095397	ENSG00000161888
Uniprot IDs		B9EGE6 Q9P202	B4E086 Q8NBT2
PDB IDs		1UEZ 1UF1 1UFX 6KZ1	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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