WHRN and BMI1

Data Source:
BioGRID (two hybrid)

		WHRN	BMI1
Description		whirlin	BMI1 proto-oncogene, polycomb ring finger
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Tip Ciliary Basal Body Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Zinc Ion Binding RING-like Zinc Finger Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Segment Specification Regulation Of Gene Expression Hemopoiesis Histone H2A-K119 Monoubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of G0 To G1 Transition
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases		Usher syndrome (US) Deafness, autosomal recessive	Penile cancer
GWAS			Prostate-specific antigen levels ( 28139693)
Interacting Genes		17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN	42 interacting genes: CASC9 CBX8 CEP126 CSNK2B E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16
Entrez ID		25861	648
HPRD ID		09718	01277
Ensembl ID		ENSG00000095397	ENSG00000168283
Uniprot IDs		B9EGE6 Q9P202	P35226
PDB IDs		1UEZ 1UF1 1UFX 6KZ1	2H0D 2NA1 3RPG 4R8P 5FR6
Enriched GO Terms of Interacting Partners?
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