HAAO and GAD1

Data Source:
HPRD (two hybrid)

		HAAO	GAD1
Description		3-hydroxyanthranilate 3,4-dioxygenase	glutamate decarboxylase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Cell Cortex Vesicle Membrane Axon Terminus Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	3-hydroxyanthranilate 3,4-dioxygenase Activity Protein Binding Ferrous Iron Binding Electron Transfer Activity	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Tryptophan Catabolic Process NAD Biosynthetic Process Response To Zinc Ion Quinolinate Biosynthetic Process Electron Transport Chain 'de Novo' NAD Biosynthetic Process From Tryptophan Anthranilate Metabolic Process Response To Cadmium Ion Quinolinate Metabolic Process Neuron Cellular Homeostasis	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Social Behavior Locomotory Exploration Behavior Neurotransmitter Biosynthetic Process Response To Drug
Pathways		Tryptophan catabolism	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases			Cerebral palsy
GWAS		Birth weight ( 31043758) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Glucose homeostasis traits ( 25524916) Hypospadias ( 25108383) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 27841878 28739976) White matter hyperintensity burden ( 25663218)	Menopause (age at onset) ( 26414677)
Interacting Genes		4 interacting genes: ARHGDIA GAD1 POT1 TERF2IP	15 interacting genes: AGTRAP CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE STK3 TRIM23 TRIP6
Entrez ID		23498	2571
HPRD ID		05158	12011
Ensembl ID		ENSG00000162882	ENSG00000128683
Uniprot IDs		P46952	A0A0S2Z3V5 Q8IVA8 Q99259
PDB IDs		2QNK 5TK5 5TKQ	2OKJ 3VP6
Enriched GO Terms of Interacting Partners?
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