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XRCC6 and PAFAH1B3
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
XRCC6
PAFAH1B3
Description
X-ray repair cross complementing 6
platelet activating factor acetylhydrolase 1b catalytic subunit 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
Membrane
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Ficolin-1-rich Granule Lumen
Cytoplasm
Cytosol
1-alkyl-2-acetylglycerophosphocholine Esterase Complex
Membrane
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Cyclin Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Platelet-activating Factor Acetyltransferase Activity
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
DNA Ligation
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Brain Development
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Smooth Muscle Cell Proliferation
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Lipid Metabolic Process
Spermatogenesis
Nervous System Development
Brain Development
Lipid Catabolic Process
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
COPI-independent Golgi-to-ER retrograde traffic
Drugs
(1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
Diseases
GWAS
Breast cancer (
29059683
)
Meat-related diet (
32066663
)
Neuroticism (
29255261
)
Pulse pressure (
28135244
)
Refractive error (
32231278
)
Interacting Genes
135 interacting genes:
ABCD4
ABL1
ACD
ADCY7
APEX1
AR
ARAP1
ATP23
ATP6V1E1
BARD1
BAZ1A
BTG1
CAPN11
CBX5
CCNA1
CCT3
CD40
CDCA5
CDK2
CDKN1A
CEBPA
CENPU
CHAF1A
CHEK1
CLTC
CLU
CMTM6
COIL
COPB1
CREBBP
CSNK2A1
CTBP2
DLX2
DNTT
DUX4
DYSF
EFNA1
EGFR
EID1
ELF3
EP300
EPS8
ETS1
FMNL1
GAL3ST4
GSE1
GZMA
GZMB
HERPUD1
HMGA2
HOXB7
HOXC4
HOXD4
HSF1
HTT
ILVBL
JPT2
KAT2A
KAT2B
KIAA0408
LIG3
MAP2K5
MAP4K2
MAPK8
MRE11
MSX2
NAA15
NCF4
NCL
NCOA6
NIT1
NOTCH1
PAEP
PAFAH1B3
PARP1
PCNA
PDK1
PDPK1
PDX1
PECAM1
PGAM1
PGR
PIN1
PLGRKT
PNRC2
POR
POU2F1
POU2F2
PRKDC
PRPF40A
PTEN
PTTG1
QRSL1
RASA1
RBBP4
RGS2
RNF126
RNF146
RPLP1
RPS10
RRAS2
RUNX2
SDHC
SELENOF
SERPINA2
SERPINB9
SET
SGO1
SIRT3
SKIL
SMAD3
SMAD7
SNTA1
SNU13
SPARC
SUMO2
TAC1
TADA3
TBCD
TCF4
TERF2
TERF2IP
TERT
TOP1
TP53
UBC
USP14
VAV1
VBP1
WBP4
WRN
XRCC5
YWHAZ
ZBTB7A
ZNF512B
36 interacting genes:
BRD7
CCDC90B
CHMP7
COPS6
CRMP1
DDX24
ECH1
EEF1A1
ERG28
GAPDH
GBP2
GDF9
HSPH1
IGSF21
LNX1
LRIF1
MED31
MEI4
NIF3L1
PAFAH1B1
PAFAH1B2
PICK1
PLEKHM1
RBM48
SDCBP2
SETDB1
SUMO4
TERF1
TERF2IP
TLE1
TP53
TUBB2A
UNC119
XRCC6
ZBTB16
ZHX1
Entrez ID
2547
5050
HPRD ID
01071
04354
Ensembl ID
ENSG00000196419
ENSG00000079462
Uniprot IDs
A0A024R1N4
B1AHC9
B4DE32
B4E356
P12956
A0A024R0L6
Q15102
PDB IDs
1JEQ
1JEY
1JJR
3RZX
5Y3R
6ERF
6ERG
6ERH
6ZHA
6ZHE
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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