XRCC6 and TERT

Data Source:
HPRD (in vitro, in vivo)

		XRCC6	TERT
Description		X-ray repair cross complementing 6	telomerase reverse transcriptase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Neutrophil Degranulation Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining	Telomere Maintenance Transcription, RNA-templated RNA-dependent DNA Biosynthetic Process Telomere Maintenance Via Telomerase Mitochondrion Organization Negative Regulation Of Gene Expression DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Regulation Of Protein Stability Positive Regulation Of Protein Binding Positive Regulation Of Hair Cycle Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Glucose Import Response To Cadmium Ion Positive Regulation Of Nitric-oxide Synthase Activity Double-stranded RNA Biosynthetic Process Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Transdifferentiation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Beta-catenin-TCF Complex Assembly Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex
Drugs			Zidovudine Grn163l Tertomotide
Diseases			Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
GWAS		Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)	Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Basal cell carcinoma ( 31174203 19151717 24403052 25855136) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 24163127 20972438) Breast cancer ( 22037553 29059683 23535729 23535733 27117709 28171663) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 28165464 26956414) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21827660 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Idiopathic pulmonary fibrosis ( 31710517 18835860) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 20700438 28604730 19836008 22797724 20871597 27393504) Lung cancer ( 21725308 23143601 27393504 18978790) Lung cancer in never smokers ( 31009812 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Nasopharyngeal carcinoma ( 27436580 26545403) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 29422604 27579533 25086665) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 31562322 21743467 25939597) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 29403010 32888494 20139978 27863252) Serum prostate-specific antigen levels ( 21160077) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 29403010 32888494 27863252)
Interacting Genes		135 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT DUX4 DYSF EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TOP1 TP53 UBC USP14 VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B	80 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HSP90AA1 HSPA4 IREB2 MAP2K3 MAP2K5 MAP3K5 MCRS1 MDM2 MET MTOR MYC NCL NF2 NSD3 PABPC1 PBK PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ
Entrez ID		2547	7015
HPRD ID		01071	01754
Ensembl ID		ENSG00000196419	ENSG00000164362
Uniprot IDs		A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956	O14746
PDB IDs		1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE	2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW
Enriched GO Terms of Interacting Partners?
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