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XRCC6 and MRE11
Data Source:
HPRD
(in vivo, two hybrid)
XRCC6
MRE11
Description
X-ray repair cross complementing 6
MRE11 homolog, double strand break repair nuclease
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
Membrane
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Ficolin-1-rich Granule Lumen
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Cyclin Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
DNA Helicase Activity
Double-stranded DNA Binding
Nuclease Activity
Endodeoxyribonuclease Activity
Protein Binding
Protein C-terminus Binding
3'-5' Exonuclease Activity
5'-3' Exonuclease Activity
Manganese Ion Binding
Identical Protein Binding
Cadherin Binding
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
DNA Ligation
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Brain Development
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Smooth Muscle Cell Proliferation
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Regulation Of Mitotic Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Sister Chromatid Cohesion
Mitotic G2 DNA Damage Checkpoint
Homologous Chromosome Pairing At Meiosis
Reciprocal Meiotic Recombination
Cell Population Proliferation
Viral Process
Intra-S DNA Damage Checkpoint
Telomeric 3' Overhang Formation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Telomere Maintenance
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Meiotic DNA Double-strand Break Formation
Negative Regulation Of Apoptotic Process
Mitochondrial Double-strand Break Repair Via Homologous Recombination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Cytosolic sensors of pathogen-associated DNA
DNA Damage/Telomere Stress Induced Senescence
IRF3-mediated induction of type I IFN
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS
Breast cancer (
29059683
)
Meat-related diet (
32066663
)
Neuroticism (
29255261
)
Pulse pressure (
28135244
)
Refractive error (
32231278
)
Interacting Genes
135 interacting genes:
ABCD4
ABL1
ACD
ADCY7
APEX1
AR
ARAP1
ATP23
ATP6V1E1
BARD1
BAZ1A
BTG1
CAPN11
CBX5
CCNA1
CCT3
CD40
CDCA5
CDK2
CDKN1A
CEBPA
CENPU
CHAF1A
CHEK1
CLTC
CLU
CMTM6
COIL
COPB1
CREBBP
CSNK2A1
CTBP2
DLX2
DNTT
DUX4
DYSF
EFNA1
EGFR
EID1
ELF3
EP300
EPS8
ETS1
FMNL1
GAL3ST4
GSE1
GZMA
GZMB
HERPUD1
HMGA2
HOXB7
HOXC4
HOXD4
HSF1
HTT
ILVBL
JPT2
KAT2A
KAT2B
KIAA0408
LIG3
MAP2K5
MAP4K2
MAPK8
MRE11
MSX2
NAA15
NCF4
NCL
NCOA6
NIT1
NOTCH1
PAEP
PAFAH1B3
PARP1
PCNA
PDK1
PDPK1
PDX1
PECAM1
PGAM1
PGR
PIN1
PLGRKT
PNRC2
POR
POU2F1
POU2F2
PRKDC
PRPF40A
PTEN
PTTG1
QRSL1
RASA1
RBBP4
RGS2
RNF126
RNF146
RPLP1
RPS10
RRAS2
RUNX2
SDHC
SELENOF
SERPINA2
SERPINB9
SET
SGO1
SIRT3
SKIL
SMAD3
SMAD7
SNTA1
SNU13
SPARC
SUMO2
TAC1
TADA3
TBCD
TCF4
TERF2
TERF2IP
TERT
TOP1
TP53
UBC
USP14
VAV1
VBP1
WBP4
WRN
XRCC5
YWHAZ
ZBTB7A
ZNF512B
20 interacting genes:
ATM
ATR
CCNE1
CDK2
DCLRE1C
DYNLL1
EP300
FANCD2
H2AX
LIG1
MAPK8IP2
NBN
NEK1
PRKDC
RAD50
RECQL5
SPOP
SUMO1
SUMO2
XRCC6
Entrez ID
2547
4361
HPRD ID
01071
02889
Ensembl ID
ENSG00000196419
ENSG00000020922
Uniprot IDs
A0A024R1N4
B1AHC9
B4DE32
B4E356
P12956
A0A024R395
F8W7U8
P49959
Q05D78
PDB IDs
1JEQ
1JEY
1JJR
3RZX
5Y3R
6ERF
6ERG
6ERH
6ZHA
6ZHE
3T1I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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