NR5A2 and NR0B2

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		NR5A2	NR0B2
Description		nuclear receptor subfamily 5 group A member 2	nuclear receptor subfamily 0 group B member 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Intracellular Receptor Signaling Pathway Epithelial Cell Differentiation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pancreas Morphogenesis Calcineurin-mediated Signaling Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Bile Acid And Bile Salt Transport Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Estrogen-dependent gene expression	Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 27579533 26098869 25086665) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)
Interacting Genes		21 interacting genes: ALB BCKDK DDB2 EDF1 FTH1 GTF2H2C NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SREBF1 UBE2I	51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10
Entrez ID		2494	8431
HPRD ID		06830	05219
Ensembl ID		ENSG00000116833	ENSG00000131910
Uniprot IDs		F1D8R9 O00482	Q15466
PDB IDs		1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VIF	1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M
Enriched GO Terms of Interacting Partners?
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