PLA2G15 and PLEKHG4

Data Source:
BioGRID (biochemical)

		PLA2G15	PLEKHG4
Description		phospholipase A2 group XV	pleckstrin homology and RhoGEF domain containing G4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Lysosome Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Lysophospholipase Activity Triglyceride Lipase Activity Phospholipid Binding Zinc Ion Binding O-acyltransferase Activity Phospholipase A1 Activity Acylglycerol O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Diacylglycerol Biosynthetic Process Phosphatidylserine Metabolic Process Ceramide Metabolic Process Fatty Acid Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylethanolamine Catabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process	Regulation Of Catalytic Activity
Pathways		Hydrolysis of LPC
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 28869591) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: IMMT RNF7	65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		23659	25894
HPRD ID		07128	10890
Ensembl ID		ENSG00000103066	ENSG00000196155
Uniprot IDs		Q8NCC3	A0A024R6X4 Q58EX7
PDB IDs		4X90 4X91 4X92 4X93 4X94 4X95 4X97 6MTW
Enriched GO Terms of Interacting Partners?
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