CASP4 and IL37

Data Source:
BioGRID (enzymatic study)

		CASP4	IL37
Description		caspase 4	interleukin 37
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Extracellular Region Extracellular Space Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Protein Autoprocessing Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptosis Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta	Inflammatory Response To Antigenic Stimulus Inflammatory Response Immune Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus
Pathways		NOD1/2 Signaling Pathway	Interleukin-37 signaling Interleukin-18 signaling
Drugs		Incadronic acid
Diseases
GWAS		Major depressive disorder ( 29317602)	Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)
Interacting Genes		16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63
Entrez ID		837	27178
HPRD ID		04047	05695
Ensembl ID		ENSG00000196954	ENSG00000125571
Uniprot IDs		P49662	Q9NZH6
PDB IDs		6KMZ 6NRY	5HN1 6NCU
Enriched GO Terms of Interacting Partners?
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