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CASP2 and NOD1
Data Source:
HPRD
(in vivo)
CASP2
NOD1
Description
caspase 2
nucleotide binding oligomerization domain containing 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Cytoplasm
Cytosol
Basolateral Plasma Membrane
Apical Plasma Membrane
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Pattern Recognition Receptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Biological Process
Luteolysis
Neural Retina Development
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Brain Development
Aging
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Protein Processing
Ectopic Germ Cell Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Cellular Response To Mechanical Stimulus
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Positive Regulation Of Apoptotic Signaling Pathway
Activation Of MAPK Activity
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Defense Response
Inflammatory Response
Signal Transduction
JNK Cascade
Detection Of Biotic Stimulus
Positive Regulation Of Cell Death
Detection Of Bacterium
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Defense Response To Bacterium
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Muramyl Dipeptide
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Xenophagy
Pathways
NOD1/2 Signaling Pathway
NADE modulates death signalling
TP53 Regulates Transcription of Caspase Activators and Caspases
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Drugs
Diseases
GWAS
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Knee osteoarthritis (
27696742
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
31 interacting genes:
ADCYAP1
BAG4
BID
CASP10
CASP14
CASP3
CASP7
CASP8
CCND3
CFLAR
CRADD
CSNK2A1
DCTN1
DSP
EEF1A1
GOLGA3
GRB2
KPNA2
MDM2
MZB1
NLRP1
NOD1
NOL3
PIDD1
PRKAB2
RAI1
RB1
RPL30
RXRA
SUMO1
UBE2I
13 interacting genes:
ATG16L1
CARD6
CASP1
CASP2
CASP4
CASP8
CASP9
GABRB1
NLRP1
RIPK2
RNF34
SOX8
XIAP
Entrez ID
835
10392
HPRD ID
02800
05815
Ensembl ID
ENSG00000106144
ENSG00000106100
Uniprot IDs
A0A087WYM1
A0A0S2Z3H1
D3DXD9
P42575
A0A024RA73
G3XAL1
Q9Y239
PDB IDs
1PYO
2P2C
3R5J
3R6G
3R6L
3R7B
3R7N
3R7S
3RJM
6GKF
6GKG
6S9K
6SAD
2B1W
2DBD
2NSN
2NZ7
4E9M
4JQW
Enriched GO Terms of Interacting Partners
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