CASP2 and CCND3

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		CASP2	CCND3
Description		caspase 2	cyclin D3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Luteolysis Neural Retina Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases	Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean corpuscular hemoglobin concentration ( 32888494 28017375) Mean corpuscular volume ( 23263863 29403010 32888494 28453575 20139978 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I	56 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 VDR
Entrez ID		835	896
HPRD ID		02800	00452
Ensembl ID		ENSG00000106144	ENSG00000112576
Uniprot IDs		A0A087WYM1 A0A0S2Z3H1 D3DXD9 P42575	B3KP19 D6RI00 P30281 Q5T8J1
PDB IDs		1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD	3G33
Enriched GO Terms of Interacting Partners?
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