SF3B3 and RAD9A

Data Source:
BioGRID (two hybrid)

		SF3B3	RAD9A
Description		splicing factor 3b subunit 3	RAD9 checkpoint clamp component A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2 SnRNP U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Checkpoint Clamp Complex
	Molecular Function	Nucleic Acid Binding Protein Binding U2 SnRNA Binding Protein-containing Complex Binding	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of Protein Catabolic Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs		Quercetin
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		104 interacting genes: APBB1 EFTUD2 EPS8 ERCC6 ERG HCK HGS HSPB1 KLF10 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPP3 NAGK NOL12 OSGEP PHF5A PPIL1 PRPF40A RAD9A RBM6 RUFY2 SF3B1 SF3B6 SMAD5 SNRNP200 SREK1 TAF9 TCERG1 TOE1 U2AF2 WBP4 WWOX YWHAG ZNF579	38 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		23450	5883
HPRD ID		12027	04788
Ensembl ID		ENSG00000189091	ENSG00000172613
Uniprot IDs		A8K6V3 Q15393	Q99638
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q	3A1J 3G65 3GGR 6HM5 6J8Y
Enriched GO Terms of Interacting Partners?
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