PUM2 and MIR221

Data Source:
BioGRID (unspecified method)

		PUM2	MIR221
Description		pumilio RNA binding family member 2	microRNA 221
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Perinuclear Region Of Cytoplasm	Extracellular Space Extracellular Vesicle
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Stress Granule Assembly Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of MRNA Stability Regulation Of Chromosome Segregation Regulation Of Gene Silencing By MiRNA Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA	Negative Regulation Of Cell Population Proliferation Response To Glucose Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Interleukin-21 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Regeneration Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Necroptotic Process Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Schwann Cell Migration Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Negative Regulation Of Double-strand Break Repair
Pathways		Neddylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		24 interacting genes: AURKA DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1	87 interacting genes: ADARB1 AIMP2 APOBEC3B AQR C1QBP CELF1 CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		23369	407006
HPRD ID		09527
Ensembl ID		ENSG00000055917	ENSG00000207870
Uniprot IDs		A0A0A0MR59 B7ZL34 Q8TB72
PDB IDs		3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?
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