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MIR221 and LIN28B
Data Source:
BioGRID
(unspecified method)
MIR221
LIN28B
Description
microRNA 221
lin-28 homolog B
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Extracellular Vesicle
Nucleoplasm
Nucleolus
Cytosol
Molecular Function
MRNA Binding Involved In Posttranscriptional Gene Silencing
RNA Binding
Protein Binding
Zinc Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Cell Population Proliferation
Response To Glucose
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Interleukin-21 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Axon Regeneration
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Adhesion Molecule Production
Negative Regulation Of Necroptotic Process
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Schwann Cell Migration
Negative Regulation Of Hematopoietic Stem Cell Proliferation
Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Negative Regulation Of Double-strand Break Repair
MiRNA Catabolic Process
Pre-miRNA Processing
RNA 3'-end Processing
RNA Destabilization
Positive Regulation Of MiRNA Catabolic Process
Negative Regulation Of Pre-miRNA Processing
Negative Regulation Of Primary MiRNA Processing
Pathways
Drugs
Diseases
GWAS
Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) (
28560309
)
Age at voice drop (
27182965
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body size at age 10 (
32376654
)
Digit length ratio (
29659830
20303062
)
Digit length ratio (left hand) (
29659830
)
Digit length ratio (right hand) (
29659830
)
Height (
28552196
20881960
25282103
25429064
23563607
18391950
18391951
)
Hip circumference adjusted for BMI (
25673412
)
Insomnia (
32332799
)
Intraocular pressure (
29617998
30054594
)
Major depressive disorder (
27479909
)
Menarche (age at onset) (
19448620
19448622
19448623
27182965
21102462
23667675
29773799
25231870
)
Menarche and menopause (age at onset) (
19448621
)
Metabolite levels (
23823483
)
Neuroblastoma (
22941191
)
Pubertal anthropometrics (
23449627
)
Puberty onset (
24770850
)
Puberty onset (breast development) (
24770850
)
Schizophrenia (
28991256
30285260
)
Sporadic neuroblastoma (
28545128
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in inactive individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for BMI in smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
28448500
)
White blood cell count (
32888494
)
Interacting Genes
87 interacting genes:
ADARB1
AIMP2
APOBEC3B
AQR
C1QBP
CELF1
CPSF1
DARS1
DDX1
DDX21
DDX3X
DHX36
EIF2AK2
EPRS1
ERAL1
FAM98A
FIP1L1
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LARS1
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI1
MSI2
MYEF2
NOL6
NONO
NUDT21
PDCD11
PLOD1
PRMT1
PTBP1
PTBP3
PUF60
PUM2
PURA
QARS1
RARS1
RBFOX2
RBM14
RBM4
RTCB
SART3
SF3A1
SF3A3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SUGP2
SYNCRIP
TAF15
TRA2A
TRA2B
TRIM25
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZNF346
45 interacting genes:
KAT2B
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR143
MIR145
MIR15A
MIR19B1
MIR200A
MIR205
MIR206
MIR221
MIR25
MIR29A
MIR29B1
MIR29B2
MIR31
MIR34A
MIR34B
MIR429
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
TRIM71
Entrez ID
407006
389421
HPRD ID
13366
Ensembl ID
ENSG00000207870
ENSG00000187772
Uniprot IDs
A0A1B0GVD3
Q6ZN17
PDB IDs
4A4I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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