SIN3B and COPS2

Data Source:
BioGRID (pull down)

		SIN3B	COPS2
Description		SIN3 transcription regulator family member B	COP9 signalosome subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Lipid Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	38 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446
Entrez ID		23309	9318
HPRD ID		09691	05146
Ensembl ID		ENSG00000127511	ENSG00000166200
Uniprot IDs		B7Z392 M0QYC5 O75182	P61201 Q59EL2
PDB IDs			4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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