SIN3B and RNF220

Data Source:
BioGRID (enzymatic study)

		SIN3B	RNF220
Description		SIN3 transcription regulator family member B	ring finger protein 220
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome	Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Lipid Metabolic Process	Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 30804561) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Interleukin-6 levels ( 22205395) Resting heart rate ( 29769521 27798624)
Interacting Genes		20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	7 interacting genes: GOPC PTGER4 SIN3B UBE2D2 UBE2D3 UBE2L3 USP7
Entrez ID		23309	55182
HPRD ID		09691	13336
Ensembl ID		ENSG00000127511	ENSG00000187147
Uniprot IDs		B7Z392 M0QYC5 O75182	Q5VTB9
PDB IDs
Enriched GO Terms of Interacting Partners?
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