SCFD1 and HECTD1

Data Source:
BioGRID (affinity chromatography technology)

		SCFD1	HECTD1
Description		sec1 family domain containing 1	HECT domain E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi-associated Vesicle Cis-Golgi Network Cytosol Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Syntaxin Binding Protein-containing Complex Binding Protein N-terminus Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Morphogenesis Response To Hypoxia Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Post-Golgi Vesicle-mediated Transport Vesicle Docking Involved In Exocytosis Response To Toxic Substance Vesicle-mediated Transport COPII Vesicle Coating Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Toxin Transport Negative Regulation Of Autophagosome Assembly	Heart Valve Development Ventricular Septum Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Anatomical Structure Development Protein K63-linked Ubiquitination
Pathways		COPII-mediated vesicle transport	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793 27455348) Cognitive decline (age-related) ( 28078323) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: DLST PPBP STX5 USO1 USP22	8 interacting genes: HRAS HSPB1 IGSF1 MTNR1B UBE2D2 UBE2D3 UBE2L3 YWHAG
Entrez ID		23256	25831
HPRD ID		10210	17098
Ensembl ID		ENSG00000092108	ENSG00000092148
Uniprot IDs		B7Z5N7 B7Z738 Q8WVM8	Q9ULT8
PDB IDs			2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?
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