PHLPP1 and SUGT1

Data Source:
BioGRID (enzymatic study)

		PHLPP1	SUGT1
Description		PH domain and leucine rich repeat protein phosphatase 1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Kinetochore Nucleus Cytosol Protein-containing Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding
	Biological Process	Regulation Of T Cell Anergy Protein Dephosphorylation Apoptotic Process Signal Transduction Entrainment Of Circadian Clock Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of Protein Kinase B Signaling Regulation Of P38MAPK Cascade	Mitotic Cell Cycle Regulation Of Protein Stability Positive Regulation By Host Of Symbiont Catalytic Activity Protein Stabilization
Pathways		Negative regulation of the PI3K/AKT network	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: BRAP CSNK1A1 GSK3B SLC9A3R1 SUGT1 WDR48	17 interacting genes: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PHLPP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1
Entrez ID		23239	10910
HPRD ID		15145	09160
Ensembl ID		ENSG00000081913	ENSG00000165416
Uniprot IDs		O60346	A8K7W3 B4DYC6 Q9Y2Z0
PDB IDs			1RL1
Enriched GO Terms of Interacting Partners?
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