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PHLPP1 and CSNK1A1
Data Source:
BioGRID
(enzymatic study)
PHLPP1
CSNK1A1
Description
PH domain and leucine rich repeat protein phosphatase 1
casein kinase 1 alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Intracellular Membrane-bounded Organelle
Condensed Chromosome Kinetochore
Nucleus
Cytoplasm
Centrosome
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Cilium
Membrane
Nuclear Speck
Beta-catenin Destruction Complex
Ciliary Basal Body
Keratin Filament
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Metal Ion Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Regulation Of T Cell Anergy
Protein Dephosphorylation
Apoptotic Process
Signal Transduction
Entrainment Of Circadian Clock
Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Regulation Of JNK Cascade
Negative Regulation Of Protein Kinase B Signaling
Regulation Of P38MAPK Cascade
Protein Phosphorylation
Golgi Organization
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of GTP Binding
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Pathways
Negative regulation of the PI3K/AKT network
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Activation of SMO
Activation of SMO
Drugs
Fostamatinib
Diseases
GWAS
Aggressiveness in attention deficit hyperactivity disorder (
27021288
)
Hip circumference adjusted for BMI (
28552196
)
Plateletcrit (
32888494
)
Carotid intima media thickness x smoking interaction (
32117412
)
Chronic obstructive pulmonary disease (
30804561
)
Esophageal cancer (
21642993
)
Interacting Genes
6 interacting genes:
BRAP
CSNK1A1
GSK3B
SLC9A3R1
SUGT1
WDR48
48 interacting genes:
ACTB
ADAP1
AP3B1
AP3B2
APC
AXIN1
BID
CDC25A
CHRM3
CRBN
CREM
CTNNB1
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MAPT
MDM4
NFATC3
OCLN
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
PTEN
RCC1
SLC18A2
SNCA
SQSTM1
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
UVRAG
YWHAQ
YWHAZ
ZRANB1
Entrez ID
23239
1452
HPRD ID
15145
02739
Ensembl ID
ENSG00000081913
ENSG00000113712
Uniprot IDs
O60346
B4DER9
P48729
Q6PJ06
PDB IDs
5FQD
6GZD
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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