FBXO28 and PMF1

Data Source:
BioGRID (two hybrid)

		FBXO28	PMF1
Description		F-box protein 28	polyamine modulated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleoplasm Transcription Regulator Complex Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding
	Biological Process	Protein Polyubiquitination	Transcription By RNA Polymerase II Cell Cycle Chromosome Segregation Positive Regulation Of Transcription, DNA-templated Cell Division
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Stroke ( 29531354) White matter hyperintensity burden ( 25663218)
Interacting Genes		22 interacting genes: AGGF1 CAVIN1 CSNK2A1 CTNNA3 EMILIN1 EMILIN3 EXOC7 GCC1 GK GOLGA2 GOLGA6L9 HOMER3 PLEKHF2 PMF1 PSMC3 SDCBP2 SKP1 SPAG5 STX1B TOP2A TRAF2 TRAF5	24 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L TSNAX USHBP1
Entrez ID		23219	11243
HPRD ID		12367	11441
Ensembl ID		ENSG00000143756	ENSG00000160783
Uniprot IDs		Q9NVF7	Q6P1K2
PDB IDs			5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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