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FBXO28 and PSMC3
Data Source:
BioGRID
(two hybrid)
FBXO28
PSMC3
Description
F-box protein 28
proteasome 26S subunit, ATPase 3
Image
No pdb structure
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Proteasome Complex
P-body
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Binding
Identical Protein Binding
Protein Binding
ATP Binding
ATPase Activity
Proteasome-activating ATPase Activity
Identical Protein Binding
Biological Process
Protein Polyubiquitination
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Post-translational Protein Modification
Modulation By Host Of Viral Transcription
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Alcohol use disorder (total score) (
30336701
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
28739976
27618452
)
Fruit consumption (
32066663
)
Global electrical heterogeneity phenotypes (
29622589
)
Height (
23563607
31562340
)
Hypertension (
31879980
)
Insomnia (
32332799
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Intraocular pressure (
29617998
29235454
)
Loneliness (
29970889
)
Loneliness (MTAG) (
29970889
)
Medication use (thyroid preparations) (
31015401
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Serum albumin level (
23022100
)
Sleep duration (short sleep) (
30846698
)
Systolic blood pressure (
28739976
27618452
)
White blood cell count (
29403010
)
Interacting Genes
22 interacting genes:
AGGF1
CAVIN1
CSNK2A1
CTNNA3
EMILIN1
EMILIN3
EXOC7
GCC1
GK
GOLGA2
GOLGA6L9
HOMER3
PLEKHF2
PMF1
PSMC3
SDCBP2
SKP1
SPAG5
STX1B
TOP2A
TRAF2
TRAF5
36 interacting genes:
AMOTL2
ATXN1
CAPN3
CDKN2A
CKMT1A
CKMT1B
DPY30
ECPAS
EPM2A
ERBB2
F2RL1
FBXO28
GADD45A
INSIG1
INSIG2
KDM1A
MYC
NDRG1
NDUFAB1
PSMC2
PSMC3IP
PSMC4
PSMC5
PSMC6
PSMD12
PSMD4
PSMD9
STX11
SUMO2
TRAF4
TRAF6
TXNL1
TXNRD2
UBC
UBE2I
VHL
Entrez ID
23219
5702
HPRD ID
12367
01733
Ensembl ID
ENSG00000143756
ENSG00000165916
Uniprot IDs
Q9NVF7
A0A140VK42
P17980
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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