STAB1 and ORC5

Data Source:
BioGRID (two hybrid)

		STAB1	ORC5
Description		stabilin 1	origin recognition complex subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Membrane	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Protein Disulfide Oxidoreductase Activity Low-density Lipoprotein Particle Binding	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Receptor-mediated Endocytosis Inflammatory Response Cell Adhesion Cell-cell Signaling Negative Regulation Of Angiogenesis Defense Response To Bacterium	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways		Scavenging by Class H Receptors	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 31562340) Hematocrit ( 27863252) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Schizophrenia ( 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 31511532) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		6 interacting genes: CHID1 GGA1 GGA2 GGA3 ORC5 PIK3R2	30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		23166	5001
HPRD ID		09778	09086
Ensembl ID		ENSG00000010327	ENSG00000164815
Uniprot IDs		Q9NY15	A4D0P7 O43913 Q53FC8
PDB IDs			5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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