CIC and TRIM22

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CIC	TRIM22
Description		capicua transcriptional repressor	tripartite motif containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)	Coronary artery disease ( 29212778) Malaria ( 31844061)
Interacting Genes		13 interacting genes: ATXN1 CENPJ CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22	11 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RERE TAF7 USP7 ZZZ3
Entrez ID		23152	10346
HPRD ID		10831	05951
Ensembl ID		ENSG00000079432	ENSG00000132274
Uniprot IDs		A0A0A0MQR4 Q96RK0	B4DQS5 Q8IYM9
PDB IDs		2M41 4J2J 4J2L 6JRP 6KZG 6KZH
Enriched GO Terms of Interacting Partners?
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