TRIM22 and CIC

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM22	CIC
Description		tripartite motif containing 22	capicua transcriptional repressor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Malaria ( 31844061)	Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)
Interacting Genes		11 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RERE TAF7 USP7 ZZZ3	13 interacting genes: ATXN1 CENPJ CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22
Entrez ID		10346	23152
HPRD ID		05951	10831
Ensembl ID		ENSG00000132274	ENSG00000079432
Uniprot IDs		B4DQS5 Q8IYM9	A0A0A0MQR4 Q96RK0
PDB IDs			2M41 4J2J 4J2L 6JRP 6KZG 6KZH
Enriched GO Terms of Interacting Partners?
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