CIC and SETD2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CIC	SETD2
Description		capicua transcriptional repressor	SET domain containing 2, histone lysine methyltransferase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Regulation Of Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Viral Process Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Forebrain Development Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Cell Migration Involved In Vasculogenesis Endodermal Cell Differentiation Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Stem Cell Development Defense Response To Virus Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation Histone H3-K36 Dimethylation Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)	Adult body size ( 32376654) Basophil count ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		13 interacting genes: ATXN1 CENPJ CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22	8 interacting genes: ATXN1 CIC H3-4 H3C1 HTT SIAH2 SMAD3 SPOP
Entrez ID		23152	29072
HPRD ID		10831	11043
Ensembl ID		ENSG00000079432	ENSG00000181555
Uniprot IDs		A0A0A0MQR4 Q96RK0	Q9BYW2
PDB IDs		2M41 4J2J 4J2L 6JRP 6KZG 6KZH	2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB
Enriched GO Terms of Interacting Partners?
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