CUL9 and UBE2G2

Data Source:
HPRD (two hybrid, in vitro)

		CUL9	UBE2G2
Description		cullin 9	ubiquitin conjugating enzyme E2 G2
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GO Annotations	Cellular Component	Cytosol Cullin-RING Ubiquitin Ligase Complex	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Ubiquitination Post-translational Protein Modification	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Neddylation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult hearing difficulty ( 31564434) General risk tolerance (MTAG) ( 30643258) Obesity-related traits ( 23251661) Tea consumption ( 31046077)
Interacting Genes		8 interacting genes: CYCS MTDH PLXNB3 TP53 UBE2E2 UBE2G1 UBE2G2 UBE2L3	39 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		23113	7327
HPRD ID		06317	04387
Ensembl ID		ENSG00000112659	ENSG00000184787
Uniprot IDs		Q8IWT3	P60604
PDB IDs		2JUF	2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?
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