CAND2 and UBE3C

Data Source:
HPRD (in vitro, in vivo)

		CAND2	UBE3C
Description		cullin associated and neddylation dissociated 2 (putative)	ubiquitin protein ligase E3C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Proteasome Complex Nucleus
	Molecular Function	Protein Binding TBP-class Protein Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	SCF Complex Assembly Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Creatine kinase levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HOMA-B (corrected for HOMA-IR) ( 30369944) P wave duration ( 28794112) Waist circumference adjusted for body mass index ( 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)
Interacting Genes		9 interacting genes: CIDEB CNOT3 DNAJB6 FHL2 GLP1R RBX1 SYP TBP UBE3C	12 interacting genes: APP CAND2 CCNB1 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		23066	9690
HPRD ID		19120	15604
Ensembl ID		ENSG00000144712	ENSG00000009335
Uniprot IDs		O75155	Q15386
PDB IDs			6K2C
Enriched GO Terms of Interacting Partners?
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