CAND2 and CNOT3

Data Source:
HPRD (in vitro, two hybrid)

		CAND2	CNOT3
Description		cullin associated and neddylation dissociated 2 (putative)	CCR4-NOT transcription complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Protein Binding TBP-class Protein Binding	Protein Binding
	Biological Process	SCF Complex Assembly Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Silencing By RNA Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Creatine kinase levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HOMA-B (corrected for HOMA-IR) ( 30369944) P wave duration ( 28794112) Waist circumference adjusted for body mass index ( 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		9 interacting genes: CIDEB CNOT3 DNAJB6 FHL2 GLP1R RBX1 SYP TBP UBE3C	8 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3
Entrez ID		23066	4849
HPRD ID		19120	05368
Ensembl ID		ENSG00000144712	ENSG00000088038
Uniprot IDs		O75155	A0A024R4R3 O75175
PDB IDs			4C0D 4C0G 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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