SNAPIN and MACF1

Data Source:
BioGRID (two hybrid)

		SNAPIN	MACF1
Description		SNAP associated protein	microtubule actin crosslinking factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle Manchette Lysosomal Membrane Synaptic Vesicle Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Synapse Perinuclear Region Of Cytoplasm BORC Complex Axon Cytoplasm	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane
	Molecular Function	SNARE Binding Protein Binding	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding ATPase Activity Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Intracellular Protein Transport Lysosome Organization Lysosomal Lumen Acidification Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Viral Process Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Cellular Protein-containing Complex Localization Regulation Of Protein Binding Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Protein Maturation Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 32499647 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYSF EBAG9 EEF1G ELP1 ENO3 ENTHD1 EXOC1 EXOC7 FAM114A1 FSD2 GPRASP1 HAP1 IKBIP IMMT INSYN1 KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 KRT27 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ	30 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC
Entrez ID		23557	23499
HPRD ID		06111	09750
Ensembl ID		ENSG00000143553	ENSG00000127603
Uniprot IDs		O95295	Q6ZSD7 Q9UPN3
PDB IDs			4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?
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