TNIK and DPYSL3

Data Source:
BioGRID (two hybrid)

		TNIK	DPYSL3
Description		TRAF2 and NCK interacting kinase	dihydropyrimidinase like 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Extracellular Space Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Body Synapse Exocytic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Dihydropyrimidinase Activity Protein Binding SH3 Domain Binding Filamin Binding Chondroitin Sulfate Binding Identical Protein Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Neuron Development Response To Axon Injury Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus
Pathways		Oxidative Stress Induced Senescence	CRMPs in Sema3A signaling
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)	Brain morphology (MOSTest) ( 32665545) Excessive daytime sleepiness ( 27992416) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	9 interacting genes: ACD CRMP1 DISC1 DPYSL2 DPYSL5 OTUD6A POT1 TERF1 TNIK
Entrez ID		23043	1809
HPRD ID		18206	03104
Ensembl ID		ENSG00000154310	ENSG00000113657
Uniprot IDs		Q9UKE5	A0A140VK07 Q14195 Q6DEN2 Q8IXW6
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7	4BKN 4CNS 4CNT 4CNU
Enriched GO Terms of Interacting Partners?
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