TNIK and GSE1

Data Source:
BioGRID (two hybrid)

		TNIK	GSE1
Description		TRAF2 and NCK interacting kinase	Gse1 coiled-coil protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Oxidative Stress Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cobalt levels ( 26025379) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494 27863252) Triglyceride levels x loop diuretics use interaction ( 31806883) Triglycerides ( 30275531)
Interacting Genes		37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	27 interacting genes: C1orf94 CADPS CARD10 CDC5L CEP63 CEP70 CFAP206 DGCR6 EXOSC6 GOLGA2 LENG8 NUDT18 RALBP1 RBM48 RBPMS RCOR3 RUNX1T1 SRPK2 TEKT4 TFIP11 TNIK TRAF2 TRIM27 TRIP6 TULP3 XRCC6 ZMYND19
Entrez ID		23043	23199
HPRD ID		18206	11066
Ensembl ID		ENSG00000154310	ENSG00000131149
Uniprot IDs		Q9UKE5	Q14687
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7
Enriched GO Terms of Interacting Partners?
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