USP33 and USP15

Data Source:
BioGRID (enzymatic study)

		USP33	USP15
Description		ubiquitin specific peptidase 33	ubiquitin specific peptidase 15
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Focal Adhesion VCB Complex Cell Body Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Small GTPase Binding Ubiquitin Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Protein Deubiquitination Protein Phosphopantetheinylation BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway
Pathways		Ub-specific processing proteases Regulation of expression of SLITs and ROBOs	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		14 interacting genes: CCP110 CHRM5 DDX56 DIO2 EIF6 ELOC SELENBP1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL	55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBE2S UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		23032	9958
HPRD ID		10297	05293
Ensembl ID		ENSG00000077254	ENSG00000135655
Uniprot IDs		Q8TEY7	Q9Y4E8
PDB IDs		2UZG	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1
Enriched GO Terms of Interacting Partners?
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