USP33 and DIO2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		USP33	DIO2
Description		ubiquitin specific peptidase 33	iodothyronine deiodinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Focal Adhesion VCB Complex Cell Body Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Small GTPase Binding Ubiquitin Binding	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Ub-specific processing proteases Regulation of expression of SLITs and ROBOs	Regulation of thyroid hormone activity
Drugs
Diseases
GWAS		Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)	Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		14 interacting genes: CCP110 CHRM5 DDX56 DIO2 EIF6 ELOC SELENBP1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		23032	1734
HPRD ID		10297	09027
Ensembl ID		ENSG00000077254	ENSG00000211448
Uniprot IDs		Q8TEY7	A8K845 Q92813
PDB IDs		2UZG
Enriched GO Terms of Interacting Partners?
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