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KDM1A and HDAC1
Data Source:
HPRD
(in vivo)
KDM1A
HDAC1
Description
lysine demethylase 1A
histone deacetylase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Protein-containing Complex
DNA Repair Complex
Histone Deacetylase Complex
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Sin3 Complex
NuRD Complex
Protein-containing Complex
Neuronal Cell Body
Molecular Function
RNA Polymerase II Transcription Factor Binding
P53 Binding
Chromatin Binding
Protein Binding
Transcription Factor Binding
Oxidoreductase Activity
Enzyme Binding
Nuclear Receptor Coactivator Activity
Demethylase Activity
Histone Demethylase Activity
Histone Demethylase Activity (H3-K4 Specific)
Histone Demethylase Activity (H3-K9 Specific)
Histone Demethylase Activity (H3-dimethyl-K4 Specific)
Telomeric DNA Binding
MRF Binding
Flavin Adenine Dinucleotide Binding
Androgen Receptor Binding
Telomeric Repeat-containing RNA Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
P53 Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Deacetylase Activity
Enzyme Binding
Nucleosomal DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Activating Transcription Factor Binding
Krueppel-associated Box Domain Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
E-box Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Alternative MRNA Splicing, Via Spliceosome
Positive Regulation Of Neuroblast Proliferation
Regulation Of Transcription By RNA Polymerase II
Protein Demethylation
Blood Coagulation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Neuron Projection Development
Cerebral Cortex Development
Negative Regulation Of Protein Binding
Histone H3-K9 Demethylation
Positive Regulation Of Histone Ubiquitination
Cellular Response To UV
Histone H3-K4 Demethylation
Positive Regulation Of Chromatin Binding
Neuron Maturation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Size
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Guanine Metabolic Process
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Muscle Cell Development
Response To Fungicide
Cellular Response To CAMP
Cellular Response To Gamma Radiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Cellular Protein Localization
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Heterochromatin Assembly
Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Endoderm Development
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Negative Regulation Of Gene Expression
Negative Regulation Of Myotube Differentiation
Histone Deacetylation
Hippocampus Development
Neuron Differentiation
Circadian Regulation Of Gene Expression
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation By Host Of Viral Transcription
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Endopeptidase Activity
Negative Regulation Of Androgen Receptor Signaling Pathway
Hair Follicle Placode Formation
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Histone H3 Deacetylation
Histone H4 Deacetylation
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Amyloid-beta Clearance
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
HDACs deacetylate histones
HDMs demethylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
p75NTR negatively regulates cell cycle via SC1
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Deactivation of the beta-catenin transactivating complex
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Repression of WNT target genes
Repression of WNT target genes
Regulation of TP53 Activity through Acetylation
G1/S-Specific Transcription
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Drugs
Arsenic trioxide
Zinc
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Fingolimod
Mocetinostat
Abexinostat
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Gamma glutamyl transferase levels (
29403010
)
Global electrical heterogeneity phenotypes (
29622589
)
Pulse pressure (
27841878
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
265 interacting genes:
AKAP9
ANKEF1
ANKRD23
AP1G2
AR
ARHGAP15
ARHGAP29
ASB10
ASB3
ASCC2
ATP5MF
ATP6V1B1
BAHD1
BAIAP2
BATF
BCAT1
BIRC2
BLZF1
BMP3
BRCA1
C18orf54
C4orf17
C8orf48
C8orf74
CAGE1
CARD10
CCDC121
CCDC14
CCDC172
CCDC33
CCDC74A
CCDC74B
CCDC90B
CDC23
CDC5L
CDCA4
CDCA5
CENPQ
CEP162
CEP57
CEP70
CEP76
CFAP100
COIL
CRBN
CRLF3
CSNK2A1
CSNK2A2
CTBP1
DBF4B
DNAAF4
DNAJA3
DNTTIP1
E2F1
ECI2
ELOF1
EXOC1
EXOC7
FAM161A
FAM204A
FAM9A
FIGNL1
FYCO1
FYN
GABPB2
GAS8
GATA3
GCC1
GDF9
GLYR1
GOLGA2
GOLGA6A
GPATCH2L
GSK3B
GSTCD
GTPBP2
H3-4
H3-5
H3C1
H3C14
HAUS1
HAUS3
HAUS6
HDAC1
HESX1
HOMER3
HOXA1
ID2
IFI35
IGFBP4
IK
IKBIP
IL16
IMMT
INSM1
INTS2
ISL1
ITGB3BP
ITSN2
JRK
KANSL1
KASH5
KDM5B
KIAA0408
KIFC3
KLC3
KLF3
KLHDC4
KRT15
KRT17
KRT19
KRT222
KRT31
KRT33B
KRT35
KRT38
KRT39
KRT40
KRT6A
KRT6B
KRT7
L3MBTL3
LENG8
LINC02875
LOXL4
LZTS1
MALT1
MBD3
MBD4
MCPH1
MCRS1
METTL27
MLC1
MNS1
MTA3
MTF2
MTMR9
MTO1
MYC
MYLIP
NBPF15
NBPF26
NDUFA8
NDUFS1
NECAB2
NEFL
NF2
NFE2L2
NMI
NOSTRIN
NR1H2
NR1H3
NR2C2
NR2E1
NRBF2
ODAD3
OFCC1
OIP5
OPA3
OTUB1
PBX4
PDCD5
PDE4DIP
PEX7
PFDN5
PHC2
PHF19
PHF20L1
PHF21A
PMF1
PNKP
PPARD
PPM1D
PPP1R12A
PRDM1
PRIM2
PSMC1
PSMC3
PTEN
RASSF1
RASSF2
RASSF3
RASSF8
RCOR1
RCOR3
RIOK1
RNF10
RNF168
RPRD1A
SAMD3
SEPTIN6
SERGEF
SETDB1
SF3B2
SH3GLB2
SLU7
SMAD9
SMARCD1
SMN1
SNF8
SNX15
SOCS6
SPATA22
SPATA24
SPICE1
SPRY2
SPSB1
SPZ1
SRGAP3
SSX2IP
STAT3
STX11
STX19
SUMO2
SUV39H1
TACC1
TADA3
TAL1
TDO2
TEDC2
TERF1
TEX35
TEX9
TFIP11
TLE5
TMEM266
TNFAIP1
TNNT2
TP53
TP53BP1
TP53BP2
TRAF4
TRIM39
TRIM54
TSACC
TSC1
TTC23
TTC33
UBA3
UBASH3B
UBE2I
UCHL5
UNC119
UNKL
USP28
USP7
VPS11
VPS37A
VPS37B
WASHC3
WDR83
ZBED1
ZBTB24
ZBTB39
ZCCHC17
ZFP28
ZNF280A
ZNF333
ZNF436
ZNF451
ZNF480
ZNF581
ZNF641
ZNF71
ZNF829
189 interacting genes:
APEX1
AR
ARID4A
ATF3
ATRX
BAZ2A
BCL11A
BCL3
BCL6
BCL6B
BCOR
BHLHE40
BRCA1
BRMS1
BRMS1L
BUB1
BUB1B
BUB3
CBFA2T3
CCN5
CDC20
CDH1
CDKN1A
CDYL
CHD1
CHD4
CHFR
CIITA
CREBBP
CREM
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDB2
DDX17
DHX30
DNMT1
DNMT3A
DNMT3B
DNMT3L
EED
EID2
EID2B
ELK1
ENO1
EP300
ERCC6
EZH2
FKBP3
FOXG1
FRA10F
GATA3
GCM1
GPS2
H2AC1
H3-4
H3C1
HBP1
HDAC2
HDAC3
HDAC7
HDAC9
HELLS
HEY2
HIC1
HIF1A
HIF1AN
HNRNPD
HR
HUS1
IKZF1
ING1
IRF5
JDP2
KAT5
KCTD11
KDM1A
KLF1
KLF11
KLF4
KLF5
LCOR
MAD1L1
MAGEA1
MBD2
MBD3
MBD3L2
MBD4
MDM2
MECOM
MECP2
MEN1
MIER1
MORF4L2
MTA1
MXD1
MYOD1
NCOR2
NFE4
NFKB1
NFKBIA
NKX2-5
NKX3-2
NR1D2
NR2E3
NR2F2
NR3C1
NRIP1
NUP98
PARP1
PCNA
PEX14
PHB
PHB2
PHF12
PHF21A
PIAS3
PIAS4
PITX2
PML
PPARD
PPARG
PPP2R1B
PRKACA
PRKG1
PRRG4
PTMA
RAD9A
RAP1A
RARA
RB1
RBBP4
RBBP7
RBL1
RBL2
RBP1
RBPJ
RELA
REPIN1
RFC1
RFC4
RUNX1T1
RUNX3
RUVBL2
SALL1
SAP18
SAP30
SATB1
SATB2
SENP1
SERPINB5
SETDB1
SIN3A
SIN3B
SMAD2
SMAD3
SOX6
SP1
SP3
SPEN
SPI1
STAT2
STAT3
SUDS3
SUMO2
SUV39H1
SYK
TAB2
TAL1
TFCP2
TGIF1
TGIF2
THAP11
TNIP1
TOP2A
TOP2B
TP53
TPD52L1
TRIM27
TXNIP
UBE2I
USP38
USP43
VHL
ZBTB16
ZMYND11
ZNF76
Entrez ID
23028
3065
HPRD ID
09800
03143
Ensembl ID
ENSG00000004487
ENSG00000116478
Uniprot IDs
O60341
Q13547
Q6IT96
PDB IDs
2COM
2DW4
2EJR
2H94
2HKO
2IW5
2L3D
2UXN
2UXX
2V1D
2X0L
2XAF
2XAG
2XAH
2XAJ
2XAQ
2XAS
2Y48
2Z3Y
2Z5U
3ABT
3ABU
3ZMS
3ZMT
3ZMU
3ZMV
3ZMZ
3ZN0
3ZN1
4BAY
4CZZ
4KUM
4UV8
4UV9
4UVA
4UVB
4UVC
4UXN
4XBF
5AFW
5H6Q
5H6R
5IT3
5L3B
5L3C
5L3D
5L3E
5L3F
5L3G
5LBQ
5LGN
5LGT
5LGU
5LHG
5LHH
5LHI
5X60
5YJB
6E1F
6K3E
6KGK
6KGL
6KGM
6KGN
6KGO
6KGP
6KGQ
6KGR
6NQM
6NQU
6NR5
6S35
6TE1
6VYP
6W4K
7JJL
7JJM
7JK7
1TYI
4BKX
5ICN
6Z2J
6Z2K
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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