CNKSR2 and DLG3

Data Source:
HPRD (in vitro)

		CNKSR2	DLG3
Description		connector enhancer of kinase suppressor of Ras 2	discs large MAGUK scaffold protein 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding	Protein Binding Kinase Binding Phosphatase Binding
	Biological Process	Regulation Of Signal Transduction Intracellular Signal Transduction Postsynapse Organization	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Bipolar disorder ( 31043756) Educational attainment (years of education) ( 30038396) Schizophrenia ( 25056061) Type 2 diabetes ( 30718926)	Mean platelet volume ( 32888494)
Interacting Genes		13 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK	48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		22866	1741
HPRD ID		06473	02177
Ensembl ID		ENSG00000149970	ENSG00000082458
Uniprot IDs		A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2	Q59FY1 Q92796
PDB IDs		2EAN 3BS5	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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